Phospho-PI 3 kinase p85 alpha /gamma (Tyr467/199) Polyclonal Antibody | G-AB-05757

Phospho-PI 3 kinase p85 alpha /gamma (Tyr467/199) Polyclonal Antibody | G-AB-05757 | Gentaur Antibodies

Overview: The enzyme phosphatidylinositol 3 kinase (PI3 kinase) is a lipid kinase that generates phosphatidylinositol 3, 4, 5-triphosphate in response to receptor activation in many Signal Transduction pathways. Class IA PI3Ks exist as a heterodimer of a catalytic 110 kDa (p110) and a regulatory p85 subunit (e.g. p85 alpha) . p85 alpha is an adaptor molecule that regulates the activity of the catalytic p110 subunit by binding to phosphorylated receptor tyrosine kinases (RTKs) through its SH2 domain and mediating the interaction between p110 and the plasma membrane. p85 alpha is necessary for insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues.

Category Type: Phosphorylated antibody

Research Areas: Cancer, Immunology, Signal Transduction

Synonyms: GRB1, p85 alpha, p85, P85A, Phosphatidylinositol 3 kinase associated p 85 alpha, Phosphatidylinositol 3 kinase regulatory 1, Phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 1 (p85 alpha) , Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphoinositide 3 kinase, regulatory subunit 1 (alpha) , PI3 kinase p85 subunit alpha, PI3-kinase regulatory subunit alpha, PI3-kinase subunit p85-alpha, PI3K, PI3K regulatory subunit alpha, Pik3r1, PtdIns 3 kinase p85 alpha, PtdIns-3-kinase regulatory subunit alpha, PtdIns-3-kinase regulatory subunit p85-alpha

Reactivity: Human, Mouse, Rat, Monkey

Host: Rabbit

Isotype: IgG

Gene ID:

Accession #:

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human PI 3-kinase p85/p55 around the phosphorylation site of Tyr467/199

Clone #:

Conjugation: Unconjugated

Swissprot: P27986, Q92569

Santa Cruz:

Calculated MW: 54+83 kDa

Observed MW: 55+85 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4

Purification method: Affinity purification

Application: WB, IHC-p, IF, ELISA

Dilution: WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000, ELISA 1:10000

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Phospho-PI 3 kinase p85 alpha /gamma (Tyr467/199) Polyclonal Antibody DataSheet