Phospho-PLN (T17) Polyclonal Antibody | G-AB-12611

Phospho-PLN (T17) Polyclonal Antibody | G-AB-12611 | Gentaur Antibodies

Overview: The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca (2+) -ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca (2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure, and also familial hypertrophic cardiomyopathy.

Category Type: Phosphorylated antibody

Research Areas:

Synonyms: CMD1P, CMH18, PLB, PLN

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 5350

Accession #:

Clonality:

Immunogen: A phospho specific peptide corresponding to residues surrounding T17 of human PLN

Clone #:

Conjugation: Unconjugated

Swissprot: P26678

Santa Cruz:

Calculated MW:

Observed MW:

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: IHC

Dilution: IHC 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Phospho-PLN (T17) Polyclonal Antibody DataSheet