Phospho-PLN (T17) Polyclonal Antibody | G-AB-12611
- 3 to 5 Working Days
- Human, Mouse, Rat
Phospho-PLN (T17) Polyclonal Antibody | G-AB-12611 | Gentaur Antibodies
Overview: The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca (2+) -ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca (2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure, and also familial hypertrophic cardiomyopathy.
Category Type: Phosphorylated antibody
Synonyms: CMD1P, CMH18, PLB, PLN
Reactivity: Human, Mouse, Rat
Gene ID: 5350
Immunogen: A phospho specific peptide corresponding to residues surrounding T17 of human PLN
Concentration: 1 mg/mL
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Purification method: Affinity purification
Dilution: IHC 1:50-1:200
Storage: Store at -20°C. Avoid freeze / thaw cycles.