PLN Polyclonal Antibody | G-AB-04959

PLN Polyclonal Antibody | G-AB-04959 | Gentaur Antibodies

Overview: The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca (2+) -ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca (2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure, and also familial hypertrophic cardiomyopathy.

Category Type: Polyclonal Antibody

Research Areas:

Synonyms: Cardiac phospholamban, CMD1P, CMH18, PLB, Pln, PPLA

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID:

Accession #: NP002658

Clonality: Polyclonal

Immunogen: Synthetic peptide of human PLN

Clone #:

Conjugation: Unconjugated

Swissprot: P26678

Santa Cruz:

Calculated MW:

Observed MW:

Concentration: 1.26 mg/mL

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Purification method: Antigen affinity purification

Application: IHC, ELISA

Dilution: IHC 1:50-1:100, ELISA 1:5000-1:10000

Storage: Store at -20°C. Avoid freeze / thaw cycles.

PLN Polyclonal Antibody DataSheet