Phospho-Rb (S811) Polyclonal Antibody | G-AB-12508
- 3 to 5 Working Days
Phospho-Rb (S811) Polyclonal Antibody | G-AB-12508 | Gentaur Antibodies
Overview: The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB) , bladder cancer, and osteogenic sarcoma.
Category Type: Phosphorylated antibody
Research Areas: Cancer, Cell Biology, Epigenetics and Nuclear Signaling
Synonyms: OSRC, PPP1R130, RB, p105-Rb, pRb, pp110, RB1, Rb
Gene ID: 5925
Immunogen: A synthetic phosphorylated peptide around S811 of human Rb (NP_000312.2) .
Calculated MW: 106 kDa
Observed MW: 106 kDa
Concentration: 1 mg/mL
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Purification method: Affinity purification
Application: WB, IF
Dilution: WB 1:1000-1:2000 IF 1:50-1:100
Storage: Store at -20°C. Avoid freeze / thaw cycles.