Phospho-Rb (S811) Polyclonal Antibody | G-AB-12508

Phospho-Rb (S811) Polyclonal Antibody | G-AB-12508 | Gentaur Antibodies

Overview: The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB) , bladder cancer, and osteogenic sarcoma.

Category Type: Phosphorylated antibody

Research Areas: Cancer, Cell Biology, Epigenetics and Nuclear Signaling

Synonyms: OSRC, PPP1R130, RB, p105-Rb, pRb, pp110, RB1, Rb

Reactivity: Human

Host: Rabbit

Isotype: IgG

Gene ID: 5925

Accession #:

Clonality:

Immunogen: A synthetic phosphorylated peptide around S811 of human Rb (NP_000312.2) .

Clone #:

Conjugation: Unconjugated

Swissprot: P06400

Santa Cruz:

Calculated MW: 106 kDa

Observed MW: 106 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB, IF

Dilution: WB 1:1000-1:2000 IF 1:50-1:100

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Phospho-Rb (S811) Polyclonal Antibody DataSheet