Phospho-STAT6 (Y641) Polyclonal Antibody | G-AB-12569
- 3 to 5 Working Days
Phospho-STAT6 (Y641) Polyclonal Antibody | G-AB-12569 | Gentaur Antibodies
Overview: The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X (L) , which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.
Category Type: Phosphorylated antibody
Research Areas: Cancer, Epigenetics and Nuclear Signaling, Signal Transduction
Synonyms: D12S1644, IL-4-STAT, STAT6B, STAT6C, STAT6
Gene ID: 6778
Immunogen: A phospho specific peptide corresponding to residues surrounding Y641 of human STAT6
Calculated MW: 74 kDa/81 kDa/94 kDa
Observed MW: 110 kDa
Concentration: 1 mg/mL
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Purification method: Affinity purification
Dilution: WB 1:500-1:2000
Storage: Store at -20°C. Avoid freeze / thaw cycles.