Phospho-ZAP70 (Y319) Polyclonal Antibody | G-AB-12571
- 3 to 5 Working Days
Phospho-ZAP70 (Y319) Polyclonal Antibody | G-AB-12571 | Gentaur Antibodies
Overview: This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated Signal Transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene.
Category Type: Phosphorylated antibody
Research Areas: Cancer, Immunology, Signal Transduction, Tags & Cell Markers
Synonyms: ZAP70, ADMIO2, IMD48, SRK, STCD, STD, TZK, ZAP-70
Gene ID: 7535
Immunogen: A synthetic phosphorylated peptide around Y319 of human ZAP70 (NP_001070.2) .
Concentration: 1 mg/mL
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Purification method: Affinity purification
Dilution: IF 1:50-1:200
Storage: Store at -20°C. Avoid freeze / thaw cycles.