PSTPIP1 Polyclonal Antibody | G-AB-11854

PSTPIP1 Polyclonal Antibody | G-AB-11854 | Gentaur Antibodies

Overview: This gene encodes a cytoskeletal protein that is highly expressed in hemopoietic tissues. This protein functions via its interaction with several different proteins involved in cytoskeletal organization and inflammatory processes. It binds to the cytoplasmic tail of CD2, an effector of T cell activation and adhesion, downregulating CD2-triggered adhesion. It binds PEST-type protein tyrosine phosphatases (PTP) and directs them to c-Abl kinase to mediate c-Abl dephosphorylation, thereby, regulating c-Abl activity. It also interacts with pyrin, which is found in association with the cytoskeleton in myeloid/monocytic cells and modulates immunoregulatory functions. Mutations in this gene are associated with PAPA (pyogenic sterile arthritis, pyoderma gangrenosum, and acne) syndrome. It is hypothesized that the disease-causing mutations compromise physiologic signaling necessary for the maintenance of a proper inflammatory response.

Category Type: Polyclonal Antibody

Research Areas: Signal Transduction

Synonyms: PSTPIP1, CD2BP1, CD2BP1L, CD2BP1S, H-PIP, PAPAS, PSTPIP

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 9051

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human PSTPIP1 (NP_003969.2) .

Clone #:

Conjugation: Unconjugated

Swissprot: O43586

Santa Cruz:

Calculated MW: 45 kDa/47 kDa

Observed MW: 48 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB, IHC

Dilution: WB 1:500-1:2000 IHC 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

PSTPIP1 Polyclonal Antibody DataSheet