RBL2 Polyclonal Antibody | G-AB-04707

RBL2 Polyclonal Antibody | G-AB-04707 | Gentaur Antibodies

Overview: Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Cell Biology, Epigenetics and Nuclear Signaling

Synonyms: 130 kDa retinoblastoma associated protein, 130 kDa retinoblastoma-associated protein, IB4, p130, PPAR-alpha-interacting complex protein 128, PRB2, Rb2, Rbl2, RBL2, RBR 2, RBR-2, RBR2, Retinoblastoma like 2, Retinoblastoma-like protein 2, Retinoblastoma-related protein 2, RIC128

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID:

Accession #: NP005602

Clonality: Polyclonal

Immunogen: Synthetic peptide of human RBL2

Clone #:

Conjugation: Unconjugated

Swissprot: Q08999

Santa Cruz:

Calculated MW:

Observed MW:

Concentration: 0.8 mg/mL

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Purification method: Antigen affinity purification

Application: IHC, ELISA

Dilution: IHC 1:30-1:150, ELISA 1:5000-1:10000

Storage: Store at -20°C. Avoid freeze / thaw cycles.

RBL2 Polyclonal Antibody DataSheet