RUNX1T1 Polyclonal Antibody | G-AB-09699

RUNX1T1 Polyclonal Antibody | G-AB-09699 | Gentaur Antibodies

Overview: This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t (8;21) (q22;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Epigenetics and Nuclear Signaling

Synonyms: RUNX1T1, AML1-MTG8, AML1T1, CBFA2T1, CDR, ETO, MTG8, ZMYND2

Reactivity: Human

Host: Rabbit

Isotype: IgG

Gene ID: 862

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human RUNX1T1 (NP_783554.1) .

Clone #:

Conjugation: Unconjugated

Swissprot: Q06455

Santa Cruz:

Calculated MW: 44 kDa/48 kDa/63 kDa/64 kDa/67 kDa/68 kDa

Observed MW: 67 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB

Dilution: WB 1:200-1:1000

Storage: Store at -20°C. Avoid freeze / thaw cycles.

RUNX1T1 Polyclonal Antibody DataSheet