RUNX2 Polyclonal Antibody | G-AB-10200

RUNX2 Polyclonal Antibody | G-AB-10200 | Gentaur Antibodies

Overview: This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Two regions of potential trinucleotide repeat expansions are present in the N-terminal region of the encoded protein, and these and other mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD) . Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Epigenetics and Nuclear Signaling, Developmental Biology, Stem Cells

Synonyms: RUNX2, AML3, CBF-alpha-1, CBFA1, CCD, CCD1, CLCD, OSF-2, OSF2, PEA2aA, PEBP2aA

Reactivity: Human, Mouse

Host: Rabbit

Isotype: IgG

Gene ID: 860

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human RUNX2 (NP_001019801.3) .

Clone #:

Conjugation: Unconjugated

Swissprot: Q13950

Santa Cruz:

Calculated MW: 54 kDa/55 kDa/56 kDa

Observed MW: 70 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB

Dilution: WB 1:200-1:1000

Storage: Store at -20°C. Avoid freeze / thaw cycles.

RUNX2 Polyclonal Antibody DataSheet