STRA13 Polyclonal Antibody | G-AB-12433
- 3 to 5 Working Days
STRA13 Polyclonal Antibody | G-AB-12433 | Gentaur Antibodies
Overview: DNA-binding component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS (MHF heterodimer) , crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA. Stabilizes FANCM. In complex with CENPS and FANCM (but not other FANC proteins) , rapidly recruited to blocked forks and promotes gene conversion at blocked replication forks (PubMed:20347428, PubMed:20347429) . In complex with CENPS, CENPT and CENPW (CENP-T-W-S-X heterotetramer) , involved in the formation of a functional kinetochore outer plate, which is essential for kinetochore-microtubule attachment and faithful mitotic progression. As a component of MHF and CENP-T-W-S-X complexes, binds DNA and bends it to form a nucleosome-like structure.
Category Type: Polyclonal Antibody
Research Areas: Epigenetics and Nuclear Signaling
Synonyms: CENPX, CENP-X, D9, FAAP10, MHF2, STRA13
Gene ID: 201254
Immunogen: Recombinant fusion protein of human STRA13 (NP_659435.2) .
Calculated MW: 6 kDa/7 kDa/8 kDa
Observed MW: 14 kDa
Concentration: 1 mg/mL
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Purification method: Affinity purification
Dilution: WB 1:500-1:2000
Storage: Store at -20°C. Avoid freeze / thaw cycles.