STRA13 Polyclonal Antibody | G-AB-12433

STRA13 Polyclonal Antibody | G-AB-12433 | Gentaur Antibodies

Overview: DNA-binding component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS (MHF heterodimer) , crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA. Stabilizes FANCM. In complex with CENPS and FANCM (but not other FANC proteins) , rapidly recruited to blocked forks and promotes gene conversion at blocked replication forks (PubMed:20347428, PubMed:20347429) . In complex with CENPS, CENPT and CENPW (CENP-T-W-S-X heterotetramer) , involved in the formation of a functional kinetochore outer plate, which is essential for kinetochore-microtubule attachment and faithful mitotic progression. As a component of MHF and CENP-T-W-S-X complexes, binds DNA and bends it to form a nucleosome-like structure.

Category Type: Polyclonal Antibody

Research Areas: Epigenetics and Nuclear Signaling

Synonyms: CENPX, CENP-X, D9, FAAP10, MHF2, STRA13

Reactivity: Human

Host: Rabbit

Isotype: IgG

Gene ID: 201254

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human STRA13 (NP_659435.2) .

Clone #:

Conjugation: Unconjugated

Swissprot: A8MT69

Santa Cruz:

Calculated MW: 6 kDa/7 kDa/8 kDa

Observed MW: 14 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB

Dilution: WB 1:500-1:2000

Storage: Store at -20°C. Avoid freeze / thaw cycles.

STRA13 Polyclonal Antibody DataSheet