TGFB1 Polyclonal Antibody | G-AB-05979
Gentaur Antibodies
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Gentaur Antibodies
TGFB1 Polyclonal Antibody | G-AB-05979
- SKU:
- G-AB-05979
- Availability:
- 3 to 5 Working Days
- Host:
- Rabbit
- Reactivity:
- Human, Mouse, Rat
TGFB1 Polyclonal Antibody | G-AB-05979 | Gentaur Antibodies
Overview: Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. Can promote either T-helper 17 cells (Th17) or regulatory T-cells (Treg) lineage differentiation in a concentration-dependent manner. At high concentrations, leads to FOXP3-mediated suppression of RORC and down-regulation of IL-17 expression, favoring Treg cell development. At low concentrations in concert with IL-6 and IL-21, leads to expression of the IL-17 and IL-23 receptors, favoring differentiation to Th17 cells.
Category Type: Polyclonal Antibody
Research Areas: Cancer, Cardiovascular, Metabolism, Signal Transduction, Stem Cells
Synonyms: Cartilage-inducing factor, CED, Differentiation inhibiting factor, DPD1, LAP, Latency-associated peptide, Prepro transforming growth factor beta 1, TGF beta 1, TGF beta, TGF beta 1 protein, TGF-beta 1 protein, TGF-beta-1, TGF-beta-5, TGF-beta1, TGFB, Tgfb-1, tgfb1, TGFB1, TGFbeta, TGFbeta1, Transforming Growth Factor b1, Transforming Growth Factor beta 1, Transforming growth factor beta 1a, transforming growth factor beta-1, transforming growth factor, beta 1, Transforming Growth Factor-1
Reactivity: Human, Mouse, Rat
Host: Rabbit
Isotype: IgG
Gene ID:
Accession #:
Clonality: Polyclonal
Immunogen: Synthesized peptide derived from the C-terminal region of human TGFβ1
Clone #:
Conjugation: Unconjugated
Swissprot: P01137
Santa Cruz: sc-34830/sc-31608/sc-31609/sc-146/sc-7892
Calculated MW: 44 kDa
Observed MW: 44 kDa
Concentration: 1 mg/mL
Buffer: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Purification method: Affinity purification
Application: WB, IHC-p, IF, ELISA
Dilution: WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000, ELISA 1:20000
Storage: Store at -20°C. Avoid freeze / thaw cycles.
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