TPPP Polyclonal Antibody | G-AB-12279
- 3 to 5 Working Days
- Human, Mouse, Rat
TPPP Polyclonal Antibody | G-AB-12279 | Gentaur Antibodies
Overview: Tubulin family members are globular proteins important in the assembly of microtubules. Microtubules are structural components that play important roles in mitosis, cytokinesis and vesicle transport. TPPP (Tubulin polymerization-promoting protein) , also known as p24 and p25, is a widely expressed 219 amino acid protein found in the perinuclear region of the cytoplasm. TPPP may form dimers and functions in polymerizing tubulin into double-walled tubules, polymorphic aggregates, or stabilized blocks. TPPP overexpression prevents formation of the mitotic spindle assembly and breakdown of the nuclear envelope. TPPP is phosphorylated by TPK II and is encoded by a gene that maps to human chromosome 5, which contains 181 million base pairs and comprises nearly 6% of the human genome. May play a role in the polymerization of tubulin into microtubules, microtubule bundling and the stabilization of existing microtubules, thus maintaining the integrity of the microtubule network. May play a role in mitotic spindle assembly and nuclear envelope breakdown.
Category Type: Polyclonal Antibody
Research Areas: Cancer, Signal Transduction
Synonyms: TPPP, TPPP/p25, TPPP1, p24, p25, p25alpha
Reactivity: Human, Mouse, Rat
Gene ID: 11076
Immunogen: Recombinant fusion protein of human TPPP (NP_008961.1) .
Calculated MW: 23 kDa
Observed MW: 24 kDa
Concentration: 1 mg/mL
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Purification method: Affinity purification
Application: WB, IHC
Dilution: WB 1:500-1:2000 IHC 1:50-1:200
Storage: Store at -20°C. Avoid freeze / thaw cycles.