TPPP Polyclonal Antibody | G-AB-12279

TPPP Polyclonal Antibody | G-AB-12279 | Gentaur Antibodies

Overview: Tubulin family members are globular proteins important in the assembly of microtubules. Microtubules are structural components that play important roles in mitosis, cytokinesis and vesicle transport. TPPP (Tubulin polymerization-promoting protein) , also known as p24 and p25, is a widely expressed 219 amino acid protein found in the perinuclear region of the cytoplasm. TPPP may form dimers and functions in polymerizing tubulin into double-walled tubules, polymorphic aggregates, or stabilized blocks. TPPP overexpression prevents formation of the mitotic spindle assembly and breakdown of the nuclear envelope. TPPP is phosphorylated by TPK II and is encoded by a gene that maps to human chromosome 5, which contains 181 million base pairs and comprises nearly 6% of the human genome. May play a role in the polymerization of tubulin into microtubules, microtubule bundling and the stabilization of existing microtubules, thus maintaining the integrity of the microtubule network. May play a role in mitotic spindle assembly and nuclear envelope breakdown.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Signal Transduction

Synonyms: TPPP, TPPP/p25, TPPP1, p24, p25, p25alpha

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 11076

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human TPPP (NP_008961.1) .

Clone #:

Conjugation: Unconjugated

Swissprot: O94811

Santa Cruz:

Calculated MW: 23 kDa

Observed MW: 24 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB, IHC

Dilution: WB 1:500-1:2000 IHC 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

TPPP Polyclonal Antibody DataSheet