ADO Polyclonal Antibody | G-AB-02691
- 3 to 5 Working Days
- Human, Mouse
ADO Polyclonal Antibody | G-AB-02691 | Gentaur Antibodies
Overview: Human thiol dioxygenases include cysteine dioxygenase (CDO, MIM 603943) and cysteamine (2-aminoethanethiol) dioxygenase (ADO, EC 220.127.116.11) . CDO adds 2 oxygen atoms to free cysteine, whereas ADO adds 2 oxygen atoms to free cysteamine to form hypotaurine. Mouse Ado has strong and specific dioxygenase activity in vitro towards cysteamine but not cysteine. Recombinant Ado was shown to bind iron. Overexpression of Ado in HepG2/C3A cells increased the production of hypotaurine from cysteamine. Similar results were found with human ADO. When endogenous expression of ADO was reduced by RNA-mediated interference, hypotaurine production decreased. The demonstration of high levels of ADO in brain challenges the previous assumption that most of the taurine in the brain is a consequence of CDO activity.
Category Type: Polyclonal Antibody
Research Areas: Metabolism, Signal Transduction
Synonyms: 2 aminoethanethiol dioxygenase, 2-aminoethanethiol dioxygenase, ADO 2 aminoethanethiol (cysteamine) dioxygenase, ADO, AEDO, C10orf22, Chromosome 10 open reasing frame 22, cysteamine (2-aminoethanethiol) dioxygenase (ADO) , Cysteamine dioxygenase, DKFZp564C046, FLJ14547
Reactivity: Human, Mouse
Accession #: NP_116193
Immunogen: Synthetic peptide of human ADO
Santa Cruz: sc-162492/sc-162493
Calculated MW: 30 kDa
Concentration: 0.3 mg/mL
Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Purification method: Affinity purification
Application: WB, IHC, ELISA
Dilution: WB 1:1000-1:5000, IHC 1:25-1:100
Storage: Store at -20°C. Avoid freeze / thaw cycles.
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