CA8 Polyclonal Antibody | G-AB-11742

CA8 Polyclonal Antibody | G-AB-11742 | Gentaur Antibodies

Overview: The protein encoded by this gene was initially named CA-related protein because of sequence similarity to other known carbonic anhydrase genes. However, the gene product lacks carbonic anhydrase activity (i.e., the reversible hydration of carbon dioxide) . The gene product continues to carry a carbonic anhydrase designation based on clear sequence identity to other members of the carbonic anhydrase gene family. The absence of CA8 gene transcription in the cerebellum of the lurcher mutant in mice with a neurologic defect suggests an important role for this acatalytic form. Mutations in this gene are associated with cerebellar ataxia, mental retardation, and dysequilibrium syndrome 3 (CMARQ3) . Polymorphisms in this gene are associated with osteoporosis, and overexpression of this gene in osteosarcoma cells suggests an oncogenic role. Alternative splicing results in multiple transcript variants.

Category Type: Polyclonal Antibody

Research Areas: Cancer

Synonyms: CA8, CA-RP, CA-VIII, CALS, CAMRQ3, CARP

Reactivity: Human, Mouse

Host: Rabbit

Isotype: IgG

Gene ID: 767

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human CA8 (NP_004047.3) .

Clone #:

Conjugation: Unconjugated

Swissprot: P35219

Santa Cruz:

Calculated MW:

Observed MW:

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: IHC

Dilution: IHC 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

CA8 Polyclonal Antibody DataSheet