NGEF Polyclonal Antibody | G-AB-06507

NGEF Polyclonal Antibody | G-AB-06507 | Gentaur Antibodies

Overview: Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension (By similarity) .

Category Type: Polyclonal Antibody

Research Areas: Neuroscience, Signal Transduction

Synonyms: ARHGEF27, Eph receptor-interacting exchange protein, Eph-interacting exchange protein, EPHEXIN, Ephexin-1, Guanine nucleotide exchange factor, neuronal, Neuronal guanine nucleotide exchange factor, Ngef, NGEF

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID:

Accession #: BC031573

Clonality: Polyclonal

Immunogen: Fusion protein of human NGEF

Clone #:

Conjugation: Unconjugated

Swissprot: Q8N5V2

Santa Cruz:

Calculated MW: 82 kDa

Observed MW: Refer to figures

Concentration: 0.6 mg/mL

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Purification method: Antigen affinity purification

Application: WB, IHC, ELISA

Dilution: WB 1:500-1:2000, IHC 1:30-1:150, ELISA 1:5000-1:10000

Storage: Store at -20°C. Avoid freeze / thaw cycles.

NGEF Polyclonal Antibody DataSheet