NOTCH4 Polyclonal Antibody | G-AB-06959

NOTCH4 Polyclonal Antibody | G-AB-06959 | Gentaur Antibodies

Overview: This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. This gene may be associated with susceptibility to schizophrenia in a small portion of cases. An alternative splice variant has been described but its biological nature has not been determined.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Cardiovascular, Epigenetics and Nuclear Signaling, Stem Cells

Synonyms: FLJ16302, hNotch 4, hNotch4, INT3, Neurogenic locus notch homolog protein 4, NOTC4, Notch 4, Notch 4 intracellular domain, Notch homolog 4, NOTCH3, Notch4, NOTCH4 protein

Reactivity: Human

Host: Rabbit

Isotype: IgG

Gene ID:

Accession #: NP004548

Clonality: Polyclonal

Immunogen: Synthetic peptide of human NOTCH4

Clone #:

Conjugation: Unconjugated

Swissprot: Q99466

Santa Cruz:

Calculated MW: 210 kDa

Observed MW: Refer to figures

Concentration: 0.9 mg/mL

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Purification method: Antigen affinity purification

Application: WB, IHC, ELISA

Dilution: WB 1:800-1:2000, IHC 1:30-1:150, ELISA 1:5000-1:10000

Storage: Store at -20°C. Avoid freeze / thaw cycles.

NOTCH4 Polyclonal Antibody DataSheet