RASA1 Polyclonal Antibody | G-AB-06157

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$117.36 - $334.80
SKU:
G-AB-06157
Availability:
3 to 5 Working Days
Host:
Rabbit
Reactivity:
Human, Rat
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RASA1 Polyclonal Antibody | G-AB-06157 | Gentaur Antibodies

Overview: The protein encoded by this gene is located in the cytoplasm and is part of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Mutations leading to changes in the binding sites of either protein are associated with basal cell carcinomas. Mutations also have been associated with hereditary capillary malformations (CM) with or without arteriovenous malformations (AVM) and Parkes Weber syndrome. Alternative splicing results in two isoforms where the shorter isoform, lacking the N-terminal hydrophobic region but retaining the same activity, appears to be abundantly expressed in placental but not adult tissues.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Signal Transduction

Synonyms: CM AVM, CMAVM, DKFZp434N071, GAP, GTPase activating protein, GTPase-activating protein, OTTHUMP00000222390, OTTHUMP00000222391, OTTHUMP00000222392, OTTHUMP00000222393, p120GAP, p120RASGAP, PKWS, Ras GTPase-activating protein 1, RAS p21 protein activator (GTPase activating protein) 1, Ras p21 protein activator, RASA, RASA1, RASA1, RasGAP, Triphosphatase activating protein

Reactivity: Human, Rat

Host: Rabbit

Isotype: IgG

Gene ID:

Accession #: BC033015

Clonality: Polyclonal

Immunogen: Fusion protein of human RASA1

Clone #:

Conjugation: Unconjugated

Swissprot: P20936

Santa Cruz:

Calculated MW:

Observed MW:

Concentration: 0.6 mg/mL

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Purification method: Antigen affinity purification

Application: IHC, ELISA

Dilution: IHC 1:30-1:150, ELISA 1:5000-1:10000

Storage: Store at -20°C. Avoid freeze / thaw cycles.

RASA1 Polyclonal Antibody DataSheet

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