Phospho-CHEK1 (S280) Polyclonal Antibody | G-AB-12476
- 3 to 5 Working Days
- Human, Mouse, Rat
Phospho-CHEK1 (S280) Polyclonal Antibody | G-AB-12476 | Gentaur Antibodies
Overview: The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene.
Category Type: Phosphorylated antibody
Research Areas: Cancer, Epigenetics and Nuclear Signaling
Synonyms: CHEK1, CHK1
Reactivity: Human, Mouse, Rat
Gene ID: 1111
Immunogen: A synthetic phosphorylated peptide around S280 of human CHEK1 (NP_001265.2) .
Concentration: 1 mg/mL
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Purification method: Affinity purification
Application: IHC, IF
Dilution: IHC 1:50-1:200 IF 1:50-1:200
Storage: Store at -20°C. Avoid freeze / thaw cycles.