Phospho-Estrogen Receptor alpha（S118） Polyclonal Antibody | G-AB-12521
- 3 to 5 Working Days
Phospho-Estrogen Receptor alpha（S118） Polyclonal Antibody | G-AB-12521 | Gentaur Antibodies
Overview: This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined.
Category Type: Phosphorylated antibody
Research Areas: Cancer, Epigenetics and Nuclear Signaling, Neuroscience, Signal Transduction
Synonyms: ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1, ER alpha
Gene ID: 2099
Immunogen: A phospho specific peptide corresponding to residues surrounding S118 of human Estrogen Receptor alpha
Concentration: 1 mg/mL
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Purification method: Affinity purification
Application: IHC, IF
Dilution: IHC 1:50-1:100 IF 1:100-1:200
Storage: Store at -20°C. Avoid freeze / thaw cycles.